The second the skin tissue is damage, mast cells in the tissue release histamine to trigger the inflammatory response. At the same time the capillaries and arterioles begin dilating and release blood plasma into the area as part of the inflammatory response to injury. The plasma contains nutrients, oxygen, antibodies and white blood cells to help flush away any foreign matter from the area. After the initial rush of the inflammatory response, leukocytes and the later arriving macrophages remove the dead tissue and foreign material and the fibrin net lay down in the tissue is dissolved.
Once the wound is ready to move into the regenerative phase, a sequence of events occurs, and it is all part of the regenerative phase of wound healing, “collagen synthesis”. Collagen however, cannot be synthesized in the abundance of oxygen and nutrients, and if the blood supply has been damaged, it will need to be replaced.