The glycosaminoglycans (GAG’s) make up a portion of the extracellular fluid of the dermis are made by the fibroblast and of hyaluronic acid, heparan sulfate, heparin and dermatan sulfate. The GAG’s retain water and form a gel like substance through which ions, hormones and nutrients can freely move. A main component of this gel is hyaluronic acid, which is a large polysaccharide made of glucuronic acid and glucosamine that attract water and is increased in tissues repair or growth.